September 22, 2015, Salt Lake City, Utah – A study comparing results from the ProLung EPN scan to the results of PET scans was presented at the 16th World Conference on Lung Cancer in Denver, CO 2015.  The results from this study were also published  in the Journal of Thoracic Oncology, concluding that the “EPN Scan performed favorably versus PET, especially in evaluating smaller or PET-indeterminate lesions.”  Below is the abstract of the published data:

Bioconductance Compared to 18FDG-PET in Evaluating CT-Detected Lung Lesions
Rex Yung1, Jeff O’Driscoll2, Michael Garff3, Ming Ying Zeng4

1Pulmonology, Greater Baltimore Medical Center, Townson/MD/United States of America, 2Emergency Medicine, Intermountain Health Care, Salt Lake City/UT/United States of America, 3Prolung, Salt Lake City/UT/United States of America, 4Pulmonology, Johns Hopkins School of Medicine, Baltimore/MD/United States of America

 Background: Lung cancer (LC) is the leading cause of cancer mortality. Computed tomographic (CT) screening detects LC at earlier stages but also results in finding many more smaller, benign nodules. Positron-Emission-Tomography (PET) is commonly used to evaluate suspicious lesions prior to invasive biopsies. However, PET accuracy is confounded by various factors including size, inflammation and tumor metabolic activity. Another potential biomarker of cancerous tissue is a non-invasive measure of transcutaneous bioconductance. This study compares Electro Pulmonary Nodule (EPN), a tissue bioconductance scan, to 18FDG-PET in evaluating CT detected suspicious lung lesions.

Methods: Cohort- 27 patients with suspicious nodules evaluated with both PET and EPN scanning (IRB approved protocol) prior to biopsy or long-term radiologic follow-up. An EPN Scan measuring bioconductance was performed on bilateral anatomic skin sites and results were scored as either positive or negative dependent on a defined cut-off point. The PET results were interpreted as positive, negative or indeterminate.

Results: There were 18 LCs (16 non-small […]